EXTRACELLULAR ATP AS A POSSIBLE MEDIATOR OF CELL-MEDIATED CYTOTOXICITY

被引：98

作者：

DIVIRGILIO, F ^{[1
]}

PIZZO, P ^{[1
]}

ZANOVELLO, P ^{[1
]}

BRONTE, V ^{[1
]}

COLLAVO, D ^{[1
]}

机构：

[1] INST ONCOL, IMMUNOL LAB, I-35128 PADUA, ITALY

来源：

IMMUNOLOGY TODAY | 1990年 / 11卷 / 08期

关键词：

D O I：

10.1016/0167-5699(90)90111-L

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells lyse target cells by a specialized mechanism that involves the release of soluble 'killer' mediators. While several possible mediators have been demonstrated, it is likely that others have yet to be identified. For more than two decades it has been known that exogenous ATP is lytic to many cell types. In this article Francesco Di Virgilio and colleagues propose that extracellular ATP may be a mediator of cytotoxic cell-dependent lysis. © 1990.

引用

页码：274 / 277

页数：4

共 29 条

[1]

BERKE G, 1987, TRANSPLANT P, V19, P412

[2] RESISTANCE OF CLONED CYTOTOXIC LYMPHOCYTES-T TO CELL-MEDIATED CYTOTOXICITY [J].