REPORT OF THE COMMITTEE ON THE GENETIC CONSTITUTION OF CHROMOSOME-1

The assignment of 20 loci to chromosome 1 has now been confirmed. These include two loci, GDH and SC, which were provisionally assigned in HGM 4 (1977), and the new confirmed assignment GALE (UDPGal 4-epimerase, E.C. 5.1.3.2., 22035). In addition, there are two new provisional assignments, MTR (tetrahydropteroylglutamate methyltransferase. E.C. 2.1.1.13) and PKU1 (the classical form of phenylketonuria). Two adenovirus 'uncoiling' sites were listed on chromosome 1 in HGM 4 (1977); six sites, three major and three minor, have now been reported. The major sites are A12M1 (AdV-12cms-1q) and A12M2 (AdV-12 cms-1p) and a new site, A12M3. The three minor sites have been reported but are not considered to be sufficiently defined to be included in the map. Two loci remain in the tentative group, DO (Dombrock blood group) and RP1 (retinitis, pigmentosum 1). These 28 loci are listed in a table. The majority of regional assignments given in HGM 4 (1977) remain unchanged, and the SROs are given.