INTESTINAL BACTERIAL METABOLISM OF PROTEIN AND BILE-ACIDS - ROLE IN PATHOGENESIS OF HEPATIC-DISEASE AFTER JEJUNO-ILEAL BYPASS SURGERY

被引：27

作者：

POWELLJACKSON, PR ^{[1
]}

MAUDGAL, DP ^{[1
]}

SHARP, D ^{[1
]}

GOLDIE, A ^{[1
]}

MAXWELL, JD ^{[1
]}

机构：

[1] ST GEORGES HOSP,SCH MED,LONDON SW1X 7EZ,ENGLAND

来源：

BRITISH JOURNAL OF SURGERY | 1979年 / 66卷 / 11期

关键词：

D O I：

10.1002/bjs.1800661105

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Jejunal bacterial colonization and intestinal metabolism of bile acids and protein by bacteria have been investigated in 12 patients with abnormal liver histology following jeujno‐ileal bypass surgery for obesity. Aerobic and/or anaerobic coionic flora was present in jejunal aspirates from 8 of 12 bypass patients, but in none of the controls. Intestinal protein metabolism and bile acid deconjugation (measured by urinary indican excretion and 14C‐glycocholic acid breath test) was significantly enhanced in bypass patients. Intestinal bacterial overgrowth, with abnormal intestinal metabolism by bacteria of ingested nutrients and bile acids, could contribute to hepatic disease after bypass surgery via the production of endogenous hepatotoxins. Copyright © 1979 British Journal of Surgery Society Ltd.

引用

页码：772 / 775

页数：4

共 23 条

[1] ROLE OF INTESTINAL MICROFLORA IN COLONIC PSEUDO-OBSTRUCTION COMPLICATING JEJUNOILEAL BYPASS [J].