MODEL FOR EVALUATING THE ANALGESIC EFFECT OF A NEW FIXED-RATIO COMBINATION ANALGESIC IN PATIENTS UNDERGOING ORAL-SURGERY

A special model designed for evaluating the analgesic effect of oral analgesics was based on a short-time registration period of immediate postoperative pain. One-hour intervals in pain registration and a minimum of 2 h between the tablet intake allowed a goad estimation of changes in pain levels. The patient material consisted of 112 patients and from each patient a lower impacted wisdom tooth was removed. The test model was used to compare two analgesic drugs with placebo. The two pharmacologically active preparations were Doleron® (dextropropoxyphene, acetylsalicylic acid, phenazone, caffeine and Transergan®) and Astra 2167 (dextropropoxyphene and acetylsalicylic acid). The trial was double blind and the tablets were administered according to a crossover design. There was no statistically significant difference in analgesic effect between Astra 2167 and Doleron, and both drugs were superior to placebo. Finally, the trial showed that a reduction of the number of components of a compound analgesic to some degree reduced the pain relieving effect on this particular postoperative pain. This observed reduction was, however, not statistically significant. © 1978, Munksgaard International Publishers Ltd. All rights reserved. All rights reserved.