EFFECT OF INTRAJEJUNAL ELEMENTAL DIET PERFUSION ON JEJUNAL SECRETION OF IMMUNOGLOBULINS, ALBUMIN, AND HYALURONAN IN MAN

被引:9
作者
COLOMBEL, JF
VAERMAN, JP
HALLGREN, R
DEHENNIN, JP
WAIN, E
MODIGLIANI, R
CORTOT, A
机构
[1] CHU LILLE,EXPLORAT FONCTIONNELLES DIGEST LAB,F-59037 LILLE,FRANCE
[2] CLIN UNIV ST LUC,GASTROENTEROL LAB,B-1200 BRUSSELS,BELGIUM
[3] CLIN UNIV ST LUC,EXPTL MED UNIT,B-1200 BRUSSELS,BELGIUM
[4] CATHOLIC UNIV LOUVAIN,INT INST CELLULAR & MOLEC PATHOL,B-1200 BRUSSELS,BELGIUM
[5] UNIV UPPSALA HOSP,S-75014 UPPSALA,SWEDEN
[6] HOP ST LOUIS,SERV HEPATOGASTROENTEROL,F-75010 PARIS,FRANCE
关键词
D O I
10.1136/gut.33.1.44
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The aim of this work was to study the jejunal secretion of immunoglobulins (Ig), albumin, and hyaluronan in response to jejunal perfusion of an elemental diet. A four lumen tube with a proximal occluding balloon at the angle of Treitz was used for jejunal perfusion in seven healthy volunteers (mean age 23 years). The length of the test segment was 40 cm. The jejunum was successively perfused with a control electrolyte solution for 80 minutes and with an elemental diet (containing 20.5 g/l of free amino acids and 104.2 g/l of oligosaccharides) for 100 minutes. The jejunal fluid concentrations of albumin, IgG, monomeric IgA (m-IgA), polymeric IgA (p-IgA), IgM, secretory component, and hyaluronan were measured and their jejunal outputs calculated. Within 20 minutes of starting perfusion with the elemental diet there was a significant increase in the secretion rates of albumin (x 3.3), IgG (x 5), m-IgA (x 3.7), p-IgA (x 2), IgM (x 2), and secretory component (x 1.6), but the hyaluronan secretion rate was not changed. The increase in m-IgA, p-IgA, IgM, and secretory component output suggests that intestinal perfusion of an elemental diet results in stimulation of secretory immunity. The increase in albumin and IgG output probably reflects a nutrient induced leakage from the plasma compartment.
引用
收藏
页码:44 / 47
页数:4
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