INDUCTION OF THE C-FOS PROTOONCOGENE IN RAT AMYGDALA DURING UNCONDITIONED AND CONDITIONED FEAR

被引：208

作者：

CAMPEAU, S

HAYWARD, MD

HOPE, BT

ROSEN, JB

NESTLER, EJ

DAVIS, M

机构：

[1] YALE UNIV,SCH MED,DEPT PSYCHIAT,34 PK AVE,NEW HAVEN,CT 06508

[2] YALE UNIV,DEPT PSYCHOL,NEW HAVEN,CT 06508

[3] YALE UNIV,DEPT PHARMACOL,NEW HAVEN,CT 06508

[4] CONNECTICUT MENTAL HLTH CTR,RIBICOFF RES FACIL,NEW HAVEN,CT 06508

来源：

BRAIN RESEARCH | 1991年 / 565卷 / 02期

关键词：

C-FOS; MESSENGER RNA; AMYGDALA; FEAR; CONDITIONING; RAT;

D O I：

10.1016/0006-8993(91)91669-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Induction of the nuclear proto-oncogene c-fos in rat amygdala was investigated 30-40 min following the presentation of mild footshocks (unconditioned fear) or of contextual cues associated with similar footshocks 24 h earlier (conditioned fear). Initially, it was found that handling rats for the first time elevated c-fos mRNA levels, but this response could be blocked completely by repeated handling. Unconditioned and conditioned fear both elevated amygdala c-fos mRNA dramatically above control levels.

引用

页码：349 / 352

页数：4

共 21 条

[1] MULTIPLE UNIT-ACTIVITY RECORDED FROM AMYGDALA CENTRAL NUCLEUS DURING PAVLOVIAN HEART-RATE CONDITIONING IN RABBIT [J].