FAMILIAL INCLUSION BODY MYOSITIS - EVIDENCE FOR AUTOSOMAL DOMINANT INHERITANCE

We report a kindred manifesting clinical features and muscle biopsy findings of inclusion body myositis (IBM). In this family, multiple members were affected in two generations with direct male-to-male and female-to-male transmission. This is the first reported instance of autosomal dominant inheritance in IBM, which usually occurs sporadically or, rarely, may be transmitted as an autosomal recessive disorder.