ON THE POTENTIAL ROLE OF PROOPIOMELANOCORTIN IN SKIN PHYSIOLOGY AND PATHOLOGY

被引：120

作者：

SLOMINSKI, A

PAUS, R

WORTSMAN, J

机构：

[1] SO ILLINOIS UNIV, DEPT MED, SPRINGFIELD, IL 62708 USA

[2] FREE UNIV BERLIN, UNIV HOSP RUDOLF VIRCHOW, DEPT DERMATOL, W-1000 BERLIN 33, GERMANY

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1993年 / 93卷 / 01期

关键词：

PROOPIOMELANOCORTIN; SKIN; MELANOTROPIN; ADRENOCORTICOTROPIN; ENDORPHIN; STRESS;

D O I：

10.1016/0303-7207(93)90131-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pro-opiomelanocortin (POMC) is the precursor of ACTH, alpha-MSH and beta-endorphin, neuropeptides with multiple regulatory functions. Both the pituitary gland and peripheral tissues such as mammalian skin are capable of generating POMC-derived neuropeptides. Mammalian skin is also a target for POMC products; their possible roles in skin physiology and pathology are discussed in this communication.

引用

页码：C1 / C6

页数：6

共 67 条

[1]

AMORNSIRIPANITCH S, 1989, J INVEST DERMATOL, V92, P395

[2] HORMONAL-REGULATION OF POMC GENE-EXPRESSION [J].