INSERTIONAL MUTAGENESIS IN TRANSGENIC MICE

被引：56

作者：

RIJKERS, T ^{[1
]}

PEETZ, A ^{[1
]}

RUTHER, U ^{[1
]}

机构：

[1] MED SCH HANNOVER, INST MOLEC BIOL, D-30623 HANNOVER, GERMANY

来源：

TRANSGENIC RESEARCH | 1994年 / 3卷 / 04期

关键词：

MOUSE MUTANTS; EMBRYONIC STEM CELLS; RETROVIRAL INFECTION; GENE AND ENHANCER TRAPS;

D O I：

10.1007/BF02336773

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Increasing numbers of transgenic mouse lines have resulted in several dozens of mutants created by insertional mutagenesis. The advantages of different vector systems and the problems associated with the analysis of mutations and the cloning of the affected genes are discussed in this review.

引用

页码：203 / 215

页数：13

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