A COMPARISON OF THE EFFICACY OF CETIRIZINE AND TERFENADINE - A DOUBLE-BLIND, CONTROLLED-STUDY OF CHRONIC IDIOPATHIC URTICARIA

被引：21

作者：

ANDRI, L ^{[1
]}

SENNA, GE ^{[1
]}

BETTELI, C ^{[1
]}

GIVANNI, S ^{[1
]}

ANDRI, G ^{[1
]}

LOMBARDI, C ^{[1
]}

MEZZELANI, P ^{[1
]}

机构：

[1] UNIV VERONA, IST CLIN MED, I-37100 VERONA, ITALY

来源：

ALLERGY | 1993年 / 48卷 / 05期

关键词：

ANTIHISTAMINES; CETIRIZINE; TERFENADINE; URTICARIA;

D O I：

10.1111/j.1398-9995.1993.tb02406.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

In a 20-d, double-blind, randomized, parallel study, the efficacy of cetirizine and terfenadine was compared in 30 patients with chronic idiopathic urticaria. Subjects were randomly divided into two 15-patient groups. The first group was given cetirizine (10 mg once daily); the second terfenadine (60 mg twice daily). Cetirizine proved to be more effective than terfenadine in controlling urticaria symptoms. In fact, the score of the investigators' overall assessment was significantly lower in the cetirizine-treated group than in the terfenadine-treated group. Moreover, patient evaluation by a visual analog scale and symptoms assessed on a 4-point scale showed a better improvement in the cetirizine group. The number and severity of side-effects were similar in both treatment groups.

引用

页码：358 / 365

页数：8

共 28 条

[1] EFFECT OF CETIRIZINE ON MAST CELL-MEDIATOR RELEASE AND CELLULAR TRAFFIC DURING THE CUTANEOUS LATE-PHASE REACTION [J].