INHIBITION OF TUMOR PROMOTION BY VARIOUS PALM-OIL TOCOTRIENOLS

被引：83

作者：

GOH, SH ^{[1
]}

HEW, NF ^{[1
]}

NORHANOM, AW ^{[1
]}

YADAV, M ^{[1
]}

机构：

[1] UNIV MALAYA, INST ADV STUDIES, KUALA LUMPUR 59100, MALAYSIA

来源：

INTERNATIONAL JOURNAL OF CANCER | 1994年 / 57卷 / 04期

关键词：

D O I：

10.1002/ijc.2910570415

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Inhibition of tumour promotion by various vitamin E compounds (tocopherols and tocotrienols) and some of their dimers was examined by an in vitro assay utilizing the activation of Epstein-Barr virus (EBV) early antigen (EA) expression in EBV-genome-carrying human lymphoblastoid cells. The results reveal that gamma- and delta-tocotrienols derived from palm oil exhibit a strong activity against tumour promotion by inhibiting EBV EA expression in Raji cells induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). However, alpha- and gamma-tocopherols and dimers of gamma-tocotrienol or gamma-tocopherol lack this activity. (C) 1994 Wiley-Liss, Inc.

引用

页码：529 / 531

页数：3

共 17 条

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