IDENTIFICATION OF A FETAL EXON IN THE HUMAN FAST TROPONIN-T GENE

被引：17

作者：

BRIGGS, MM

MAREADY, M

SCHMIDT, JM

SCHACHAT, F

机构：

[1] Department of Cell Biology, Duke University Medical Center, Durham, NC 27710

来源：

FEBS LETTERS | 1994年 / 350卷 / 01期

关键词：

TROPONIN T; ALTERNATIVE SPLICING; GENE EXPRESSION; HUMAN MUSCLE; FETAL EXON;

D O I：

10.1016/0014-5793(94)00729-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A developmentally regulated exon has been identified in the 5' alternatively spliced region of the human fast Troponin T (TnT) gene. Expressed in fetal (but not adult) muscle, this exon is homologous with the fetal exons recently described in the rabbit and rat fast TnT genes. They all exhibit a split codon organization and encode a highly acidic peptide. To determine if the splicing pathways, including the human fetal exon, are also conserved, we defined the major TnT splicing patterns in fetal muscle. They generate fetal TnT 1, fetal TnT 3, and TnT1f and TnT3f, species previously described in rabbit and rat skeletal muscles.

引用

页码：37 / 40

页数：4

共 25 条

[1] DOES STERIC INTERFERENCE BETWEEN SPLICE SITES BLOCK THE SPLICING OF A SHORT C-SRC NEURON-SPECIFIC EXON IN NONNEURONAL CELLS [J].