USE OF CYCLODEXTRINS AND CYCLODEXTRIN DERIVATIVES IN HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND CAPILLARY ELECTROPHORESIS

被引：55

作者：

SZEMAN, J ^{[1
]}

GANZLER, K ^{[1
]}

机构：

[1] HUNGARIAN ACAD SCI,CENT RES INST CHEM,BUDAPEST,HUNGARY

来源：

JOURNAL OF CHROMATOGRAPHY A | 1994年 / 668卷 / 02期

关键词：

D O I：

10.1016/0021-9673(94)80147-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Carboxymethyl- and carboxyethyl-beta-cyclodextrin have proved to be effective chiral mobile phase additives in HPLC for the resolution of enantiomers of hexobarbital, ephedrine and an aminomethylbenzodioxane derivative. The separations are influenced by a combination of hydrophobic and electrostatic interactions. The type and concentration of the cyclodextrin derivative and the pH and type of base used to adjust the pH can be varied in order to optimize the method. In addition, a coating procedure was developed for capillary electrophoresis. The enantiomers of epinephrine were resolved on a gamma-cyclodextrin-coated capillary. The length of the capillary has a significant effect on the resolution. beta-Cyclodextrin was found to give no resolution.

引用

页码：509 / 517

页数：9

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