FUNCTIONAL AND DEVELOPMENTAL STUDIES OF THE PERIPHERAL ARTERIAL CHEMORECEPTORS IN RAT - EFFECTS OF NICOTINE AND POSSIBLE RELATION TO SUDDEN-INFANT-DEATH-SYNDROME

被引：75

作者：

HOLGERT, H ^{[1
]}

HOKFELT, T ^{[1
]}

HERTZBERG, T ^{[1
]}

LAGERCRANTZ, H ^{[1
]}

机构：

[1] KAROLINSKA HOSP, BARNKLINIKEN, DEPT WOMAN & CHILD HLTH, S-17176 STOCKHOLM, SWEDEN

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 16期

关键词：

DOPAMINE TYPE 2 RECEPTORS; IN SITU HYBRIDIZATION; TYROSINE HYDROXYLASE;

D O I：

10.1073/pnas.92.16.7575

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The drive on respiration mediated by the peripheral arterial chemoreceptors was assessed by the hyperoxic test in 3-day-old rat pups. They accounted for 22.5 +/- 8.8% during control conditions, but only for 6.9 +/- 10.0% after nicotine exposure, an effect counteracted by blockade of peripheral dopamine type 2 receptors (DA2Rs). Furthermore, nicotine reduced dopamine (DA) content and increased the expression of tyrosine hydroxylase (TH) in the carotid bodies, further suggesting that DA mediates the acute effect of nicotine on arterial chemoreceptor function. During postnatal development TH and DA2R mRNA Levels in the carotid bodies decreased. Thus, nicotine from smoking may also interfere with the postnatal resetting of the oxygen sensitivity of the peripheral arterial chemoreceptors by increasing carotid body TH mRNA, as well as DA release in this period. Collectively these effects of nicotine on the peripheral arterial chemoreceptors may increase the vulnerability to hypoxic episodes and attenuate the protective chemoreflex response. These mechanisms may underlie the well-known relation between maternal smoking and sudden infant death syndrome.

引用

页码：7575 / 7579

页数：5