THE VALUE OF POLYMORPHONUCLEAR ELASTASE IN ADULT-RESPIRATORY-DISTRESS-SYNDROME

被引：5

作者：

DIAZ, J ^{[1
]}

TORNEL, PL ^{[1
]}

JARA, P ^{[1
]}

CANIZARES, F ^{[1
]}

EGEA, JM ^{[1
]}

MARTINEZ, P ^{[1
]}

机构：

[1] UNIV MURCIA,HOSP VIRGEN ARRIXACA,INTENS CARE UNIT,E-30120 MURCIA,SPAIN

来源：

CLINICA CHIMICA ACTA | 1995年 / 236卷 / 02期

关键词：

ELASTASE; C-REACTIVE PROTEIN; ADULT RESPIRATORY DISTRESS SYNDROME; POLYTRAUMATIZED PATIENTS; PROGNOSTIC MARKER; TISSUE NECROSIS; CRITICAL CARE; INFLAMMATORY PROCESS; ALPHA(2)-MACROGLOBULIN; ALPHA(1)-ANTITRYPSIN;

D O I：

10.1016/0009-8981(95)98129-5

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The clinical usefulness of quantitative plasma polymorphonuclear elastase (PMN-elastase) determinations as prognostic markers of adult respiratory distress syndrome (ARDS) in polytraumatized patients was analyzed. PMN-elastase and C-reactive protein (CRP) levels were determined in 55 polytraumatized patients admitted into the Intensive Care Unit. Eight patients developed ARDS and 47 patients did not. These parameters were also analyzed in a control group (n = 34). PMN-elastase levels in ARDS cases reached significantly higher values than in patients who did not develop this syndrome (P < 0.01). We conclude that the increase in plasma PMN-elastase levels can be useful in predicting the development of ARDS in polytraumatized patients, in instituting prophylactic actions and monitoring the course of the disease in these high risk patients. This test is easily adaptable to the routine of any hospital laboratory.

引用

页码：119 / 127

页数：9

共 39 条

[1] OXYGEN RADICALS - AN IMPORTANT MEDIATOR OF SEPSIS AND SEPTIC SHOCK [J].

BRIGHAM, KL .

KLINISCHE WOCHENSCHRIFT, 1991, 69 (21-23) :1004-1008

[2]

BROWER MS, 1982, J BIOL CHEM, V257, P9849

[3]

COCHRANE CG, 1988, AM J MED, V84, P75

[4]

CYBULSKY MI, 1988, LAB INVEST, V58, P365

[5]

DEAME SA, 1981, J SURG, V19, P156

[6] C-REACTIVE PROTEIN (CRP) IN INFLAMMATORY ARTICULAR DISEASES - COMPARISON OF CRP MEASUREMENTS IN BLOOD AND SYNOVIAL-FLUID [J].

DELPUECH, P ;

DESCH, G ;

MAGNAN, F ;

ARLAUD, J ;

LAMMY, S .

CLINICAL BIOCHEMISTRY, 1989, 22 (04) :305-308

[7] CLINICAL USEFULNESS OF POLYMORPHONUCLEAR ELASTASE IN PREDICTING THE SEVERITY OF ACUTE-PANCREATITIS - RESULTS OF A MULTICENTER STUDY [J].

DOMINGUEZMUNOZ, JE ;

CARBALLO, F ;

GARCIA, MJ ;

DEDIEGO, JM ;

RABAGO, L ;

SIMON, MA ;

DELAMORENA, J .

BRITISH JOURNAL OF SURGERY, 1991, 78 (10) :1230-1234

[8] ELEVATION OF PLASMA TRUNCATED ELASTASE ALPHA-1-PROTEINASE INHIBITOR COMPLEXES IN PATIENTS WITH INFLAMMATORY LUNG-DISEASES [J].

FUJITA, J ;

NAKAMURA, H ;

YAMAGISHI, Y ;

YAMAJI, Y ;

SHIOTANI, T ;

IRINO, S .

CHEST, 1992, 102 (01) :129-134

[9]

GADEK JE, 1992, AM J MED, V92, P275

[10]

HAFNER G, 1991, EUR J CLIN CHEM CLIN, V29, P179

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