GAS CHROMATOGRAPHIC IDENTIFICATION OF THIORIDAZINE IN PLASMA, AND A METHOD FOR ROUTINE ASSAY OF DRUG

被引：38

作者：

CURRY, SH

MOULD, GP

机构：

[1] Department of Pharmacology and Therapeutics, London Hospital Medical College, London, E 1, Turner Street

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1969年 / 21卷 / 10期

关键词：

D O I：

10.1111/j.2042-7158.1969.tb08144.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Thioridazine had a retention time of approximately 4 min on a 3% OV‐17 gas chromatographic column at 260°. Using flame or argon ionization detectors samples as low as 0μ01 μg could be detected. The drug could be extracted into n‐heptane containing 1·5% isoamyl alcohol or 20% toluene. Recovery of drug added to plasma was 100%. Unchanged thioridazine was identified in the plasma of two experimental samples, on the basis of chromatographic and solvent distribution data. 1969 Royal Pharmaceutical Society of Great Britain

引用

页码：674 / &

共 9 条

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