SULFONES OF POTENTIAL MEDICINAL VALUE .I. DIAZONIUM COUPLING PRODUCTS OF ETHYL P-TOLUENESULFONYLACETATE

被引：7

作者：

THOMPSON, BB

KULKARNI, PG

机构：

[1] Department of Medicinal Chemistry, School of Pharmacy, University of Georgia, Athens, Georgia

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 05期

关键词：

Ethyl p‐toluenesulfonylacetate diazonium derivatives—synthesis; IR spectrophotometry—identity; structure; NMR spectroscopy—identity; TLC—separation;

D O I：

10.1002/jps.2600580526

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A coupling of various aryldiazonium salt solutions with ethyl p‐toluenesulfonylacetate has been effected at pH 7.5–8.5. Experimental details and physical properties of the products of this reaction are given. In order to establish whether the coupled product exists as an azo or as the isomeric hydrazo, NMR and IR spectroscopic data were obtained. Both sets of data confirm that the azo form is the proper structural assignment. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：623 / &

共 10 条

[1]

ADAMS R, 1959, ORG REACTIONS, V10, P1

[2]

[Anonymous], ORG REACT

[3] The action of sodium ethylate on levo-ethyl-alpha-phenylsulfonebutyrate [J].