PHENYLACETIC ACID EXCRETION IN MAN

被引:35
作者
MARTIN, ME [1 ]
KAROUM, F [1 ]
WYATT, RJ [1 ]
机构
[1] ST ELIZABETHS HOSP, NIMH, DIV SPECIAL MENTAL HLTH RES, CLIN PSYCHOPHARMACOL LAB, WASHINGTON, DC 20032 USA
关键词
D O I
10.1016/S0003-2697(79)80008-1
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A rapid, reliable, sensitive and highly specific mass fragmentographic method for the quantification of phenylacetic acid (PAA) in [human] urine is described. The method was used to determine total, conjugated and free PAA simultaneously in normal urine. The mean .+-. SE excretion of total, conjugated and free PAA in urine of 24 normal adult volunteers were, respectively, 137.4 .+-. 15.8, 128.8 .+-. 15.0, 8.49 .+-. 0.99 mg/24 h. Free PAA constitutes < 10% of the total (free plus conjugated) urine excretion of PAA.
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页码:283 / 287
页数:5
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