EFFECTS OF DIHYDROTESTOSTERONE ON SYNTHESIS OF NUCLEIC ACID AND ATP IN PROSTATIC NUCLEI

被引：30

作者：

BASHIRELAHI, N

CHADER, GJ

VILLEE, CA

机构：

[1] Department of Biological Chemistry, Harvard Medical School, Boston

[2] Laboratory for Reproductive Biology, Boston Hospital for Women, Boston

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 37卷 / 06期

关键词：

D O I：

10.1016/0006-291X(69)90227-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of testosterone and of dihydrotestosteron on nucleic acid synthesis by isolated prostatic nuclei from castrate rats were compared. The incorporation of cytidine into acid-insoluble material was enhanced by dihydrotestosterone but not by testosterone. Orotic acid was not incorporated into the acid-insoluble material as readily as cytidine and no hormonal effects were observed. Dihydrotestosterone inhibited the incorporation of inorganic phosphate into ATP whereas testosterone showed little inhibition. These experiments demonstrate a direct effect of androgens on isolated nuclei and support the suggestion that dihydrotestosterone rather than testosterone is the active hormone species in prostatic nuclei. © 1969.

引用

页码：976 / +

页数：1

共 17 条

[1]

AARONSON SA, 1965, P SOC EXP BIOL MED, V120, P9

[2] SELECTIVE RETENTION OF DIHYDROTESTO-STERONE BY PROSTATIC NUCLEI [J].