A NEW INHIBITOR OF PROTEIN KINASE-C, RK-286C (4'-DEMETHYLAMINO-4'-HYDROXYSTAUROSPORINE) .2. ISOLATION, PHYSICOCHEMICAL PROPERTIES AND STRUCTURE

被引：37

作者：

TAKAHASHI, H ^{[1
]}

OSADA, H ^{[1
]}

URAMOTO, M ^{[1
]}

ISONO, K ^{[1
]}

机构：

[1] INST PHYS & CHEM RES,ANTIBIOT LAB,WAKO,SAITAMA 35101,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 02期

关键词：

D O I：

10.7164/antibiotics.43.168

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

RK-286C, a new inhibitor of protein kinase C, has been found by the bleb-forming assay using K562 cells. It was produced by Streptomyces sp. RK-286 and purified by solvent extraction, silica gel chromatography and preparative HPLC. Spectrometric analysis revealed that the structure is 4′-demethylamino-4′-hydroxystaurosporine. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：168 / 173

页数：6

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