COPPER AND COBALT MEDIATED REGIOSELECTIVE ALKYLATION OF POLYKETIDE MODELS - METHYL 3,5-DIOXOHEXANOATE AND TRIACETIC ACID LACTONE

被引：33

作者：

CERVELLO, J ^{[1
]}

MARQUET, J ^{[1
]}

MORENOMANAS, M ^{[1
]}

机构：

[1] UNIV AUTONOMA BARCELONA,DEPT CHEM,E-08193 BARCELONA,SPAIN

来源：

TETRAHEDRON | 1990年 / 46卷 / 06期

关键词：

D O I：

10.1016/S0040-4020(01)89770-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Regioselective C-alkylations at the intercarbonyl positions C-4 and C-2 of the polyketide model methyl 3,5-dioxohexanoate, 1, have been acomplished through reactions of its cobalt(II), 4a, and copper(II), 4b, complexes respectively. Some examples of double alkylations at both positions are presented. Cyclizations of the regioselectively substituted diketoesters so prepared gave triacetic acid lactone derivatives regioselectively alkylated at C-5 and at C-3. © 1990.

引用

页码：2035 / 2046

页数：12

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