TOBRAMYCIN PHARMACOKINETICS IN MORBIDLY OBESE PATIENTS

被引：57

作者：

BLOUIN, RA ^{[1
]}

MANN, HJ ^{[1
]}

GRIFFEN, WO ^{[1
]}

BAUER, LA ^{[1
]}

RECORD, KE ^{[1
]}

机构：

[1] UNIV KENTUCKY,MED CTR,COLL MED,DEPT SURG,LEXINGTON,KY 40536

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 1979年 / 26卷 / 04期

关键词：

D O I：

10.1002/cpt1979264508

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tobramycin kinetics were examined in 9 morbidly obese women following a single intavenous (120 mg) bolus. After the injection, serum elimination conformed to a 2-compartment open model with a and β t 1 2s of 0.285 and 2.1 hr. The volume of distribution (Varea was determined to be 0.44 1/kg ideal body weight (IBW) and 0.20 1/kg total body weight (TBW). To normalize Varea to 0.26 1/kg, 58% of the patients' adipose weight (TBW - IBW) must also be taken into account. © 1979.

引用

页码：508 / 512

页数：5

共 14 条

[1] PREDICTABILITY OF BLOOD-LEVELS OF GENTAMICIN IN MAN
BARZA, M
BROWN, RB
SHEN, D
GIBALDI, M
WEINSTEIN, L
[J]. JOURNAL OF INFECTIOUS DISEASES, 1975, 132 (02) : 165 - 174
[2] BERMAN M, 1968, USERS MANUAL SAAM
[3] CUTLER RE, 1972, J AMER MED ASSOC, V219, P1037, DOI 10.1001/jama.219.8.1037
[4] GENTAMICIN THERAPY
DEVINE, BJ
[J]. DRUG INTELLIGENCE & CLINICAL PHARMACY, 1974, 8 (11): : 650 - 655
[5] INTRAVENOUS-INJECTION OF GENTAMICIN AND TOBRAMYCIN WITHOUT IMPAIRMENT OF HEARING
DOBBS, SM
MAWER, GE
[J]. JOURNAL OF INFECTIOUS DISEASES, 1976, 134 : S114 - S117
[6] DuBois D, 1915, ARCH INTERN MED, V15, P868
[7] Gyselynek AM, 1971, J INFECT DIS, V124, P570
[8] GENTAMICIN SERUM CONCENTRATIONS - PHARMACOKINETIC PREDICTIONS
HULL, JH
SARUBBI, FA
[J]. ANNALS OF INTERNAL MEDICINE, 1976, 85 (02) : 183 - 189
[9] GENTAMICIN DOSAGES FOR RENAL INSUFFICIENCY - ADJUSTMENTS BASED ON ENDOGENOUS CREATININE CLEARANCE AND SERUM CREATININE CONCENTRATION
MCHENRY, MC
GAVAN, TL
GIFFORD, RW
GEURKINK, NA
VANOMMEN, RA
TOWN, MA
WAGNER, JG
[J]. ANNALS OF INTERNAL MEDICINE, 1971, 74 (02) : 192 - +
[10] AMIKACIN SERUM CONCENTRATIONS - PREDICTION OF LEVELS AND DOSAGE GUIDELINES
SARUBBI, FA
HULL, JH
[J]. ANNALS OF INTERNAL MEDICINE, 1978, 89 (05) : 612 - 618

← 1 2 →