MORPHINE, MORPHINE-6-GLUCURONIDE AND MORPHINE-3-GLUCURONIDE CONCENTRATIONS IN PLASMA AND CEREBROSPINAL-FLUID DURING LONG-TERM HIGH-DOSE INTRATHECAL MORPHINE ADMINISTRATION

被引：31

作者：

BIGLER, D ^{[1
]}

CHRISTENSEN, CB ^{[1
]}

ERIKSEN, J ^{[1
]}

JENSEN, NH ^{[1
]}

机构：

[1] UNIV COPENHAGEN,DEPT INTERNAL MED,DK-1168 COPENHAGEN,DENMARK

来源：

PAIN | 1990年 / 41卷 / 01期

关键词：

Intrathecal morphine; Morphine; Morphine-3-glucuronide; Morphine-6-glucuronide; Pharmacokinetics;

D O I：

10.1016/0304-3959(90)91103-P

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The kinetics of morphine, morphine-6-glucuronide (M6G) and morphine-3-glucuronide (M3G) were studied in a 56-year-old female with lung cancer. Long-term treatment with morphine intrathecally 28 mg every 6 h was used for pain control. Cerebrospinal fluid (CSF) concentrations of morphine were high with an elimination half-life of 2.1 h. The plasma/CSF ratios for M6G and M3G were 1:0.8 and 4:1, respectively, suggesting that M6G penetrates the blood-brain barrier more easily than M3G. The low CSF concentrations indicate that M6G played hardly any major analgetic role in the patient studied. © 1990.

引用

页码：15 / 18

页数：4

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