THE SYNTHESIS OF 8-(S)-FLUORO-N-TRIFLUOROACETYLIDARUBICIN

被引：16

作者：

GIOLITTI, A ^{[1
]}

GUIDI, A ^{[1
]}

PASQUI, F ^{[1
]}

PESTELLINI, V ^{[1
]}

ARCAMONE, FM ^{[1
]}

机构：

[1] A MENARINI AZIENDE FARMACEUT RIUNITE,RIC CHIM LAB,VIA SETTE SANTI 3,I-50131 FLORENCE,ITALY

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 12期

关键词：

ANTHRACYCLINES; ANTHRACYCLINONES; FLUOROANTHRACYCLINONES; ORTHOQUINODIMETHANE; DAUNOSAMINE;

D O I：

10.1016/S0040-4039(00)91694-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(+,-)4-Demethoxy-8-fluoro-(7,8-trans)-daunomycinone is obtained by total synthesis and coupled with daunosamine to give 8-(S)-fluoroidarubicin-N-trifluoroacetate, the first anthracycline substituted with a fluorine atom on ring A.

引用

页码：1637 / 1640

页数：4

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