Extracellular matrix alters epithelial differentiation

被引：148

作者：

Hay, Elizabeth D. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1993年 / 5卷 / 06期

关键词：

D O I：

10.1016/0955-0674(93)90088-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Extracellular matrix (ECM) induces and maintains the differentiation of epithelial cells, not by totally altering their state of differentiation, but by activating overt differentiation. Recent studies of cultured mammary cells provide an elegant molecular analysis of this kind of progressive cell differentiation. Other studies show that ECM can not only activate and enhance a differentiated state, but can even alter it in bringing about transformation of epithelium to mesenchyme.

引用

页码：1029 / 1035

页数：7

共 49 条

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