SANDRAMYCIN, A NOVEL ANTITUMOR ANTIBIOTIC PRODUCED BY A NOCARDIOIDES SP .2. STRUCTURE DETERMINATION

被引：36

作者：

MATSON, JA

COLSON, KL

BELOFSKY, GN

BLEIBERG, BB

机构：

[1] Myers Squibb, Pharmaceutical Research Institute, Wallingford, CT. 06492, 5 Research Parkway

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 01期

关键词：

D O I：

10.7164/antibiotics.46.162

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The structure of sandramycin, a novel antitumor antibiotic, was established by spectroscopic analysis and chiral chromatography of its acid hydrolysate. It was determined to be a cyclic decadepsipeptide with a two-fold axis of symmetry and 3-hydroxyquinaldic acid as an appended chromophore.

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页码：162 / 166

页数：5

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