BRONCHOALVEOLAR LAVAGE - QUANTITATION OF INTRAALVEOLAR FLUID

被引:64
作者
VONWICHERT, P [1 ]
JOSEPH, K [1 ]
MULLER, B [1 ]
FRANCK, WM [1 ]
机构
[1] PHILIPPS UNIV,NUKLEAR MED KLIN,DEPT RADIOL,MARBURG,GERMANY
来源
AMERICAN REVIEW OF RESPIRATORY DISEASE | 1993年 / 147卷 / 01期
关键词
D O I
10.1164/ajrccm/147.1.148
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
A precise calculation of the amount of intraalveolar fluid is the basis of a quantitative analysis of intraalveolar compounds. Different approaches have been made to cover this important problem. Here, we report a comparative study with five markers: Tc-99m-DTPA, Cr-51-EDTA, inulin, urea, and methylene blue in animal experiments as well as in human experiments. The marker substances were added to the lavage fluid, and the ''dilution'' of the markers, i.e., the alveolar fluid, was calculated. The results showed that in animals with healthy lungs the tracer methods are able to calculate amounts of intraalveolar fluid that are comparable to morphologic findings. In animals as well as in humans, methylene blue and inulin were shown to be useless in determining alveolar fluid volume compared with the tracer methods. In humans, the calculations with the urea method and with Tc-DTPA were in the same magnitude, but there was no individual correlation. We conclude that, at present, the methods to quantitate alveolar fluid volume lack precision and add nothing to a deeper understanding of alveolar biology.
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页码:148 / 152
页数:5
相关论文
共 16 条
[1]  
BAUGHMAN RP, 1983, AM REV RESPIR DIS, V128, P266
[2]  
Coates G, 1988, J Thorac Imaging, V3, P21, DOI 10.1097/00005382-198807000-00008
[3]   BRONCHOALVEOLAR LAVAGE - THE REPORT OF AN INTERNATIONAL-CONFERENCE [J].
CRYSTAL, RG ;
REYNOLDS, HY ;
KALICA, AR .
CHEST, 1986, 90 (01) :122-131
[4]  
DUSSER D, 1984, B EUR PHYSIOPATH RES, V20, P223
[5]  
EICHLER K, 1969, ERZEUGUNG KRANKHEI 2, P243
[6]   NORMAL HUMAN LUNG - ULTRASTRUCTURE AND MORPHOMETRIC ESTIMATION OF DIFFUSION CAPACITY [J].
GEHR, P ;
BACHOFEN, M ;
WEIBEL, ER .
RESPIRATION PHYSIOLOGY, 1978, 32 (02) :121-140
[7]   IMPROVEMENTS IN DEMONSTRATION OF LINING LAYER OF LUNG ALVEOLI BY ELECTRON MICROSCOPY [J].
GIL, J ;
WEIBEL, ER .
RESPIRATION PHYSIOLOGY, 1969, 8 (01) :13-+
[8]  
GROTH S, 1991, THESIS KOBENHAVN LAG
[9]  
KOHLER D, 1983, NUKLEARMED, V22, P115
[10]  
LOW RB, 1978, AM REV RESPIR DIS, V118, P863