PEROXYNITRITE CAUSES APOPTOSIS IN RAT THYMOCYTES

被引：146

作者：

SALGO, MG ^{[1
]}

SQUADRITO, GL ^{[1
]}

PRYOR, WA ^{[1
]}

机构：

[1] LOUISIANA STATE UNIV,INST BIODYNAM,BATON ROUGE,LA 70803

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 215卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.2578

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peroxynitrite is demonstrated to cause apoptosis in freshly harvested rat thymocytes suspended in phosphate buffer, as shown by the typical ladder pattern of DNA fragmentation. This evidence suggests a new function for peroxynitrite, already known to be a strong oxidant. Peroxynitrite can nick DNA, oxidize cellular thiols and initiate the apoptotic process responsible for genomic degradation. (C) 1995 Academic Press, Inc.

引用

页码：1111 / 1118

页数：8

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