COMPARATIVE 90-DAY FEEDING STUDY WITH LOW-VISCOSITY WHITE MINERAL-OIL IN FISCHER-344 AND SPRAGUE-DAWLEY-DERIVED CRL-CD RATS

被引：47

作者：

FIRRIOLO, JM ^{[1
]}

MORRIS, CF ^{[1
]}

TRIMMER, GW ^{[1
]}

TWITTY, LD ^{[1
]}

SMITH, JH ^{[1
]}

FREEMAN, JJ ^{[1
]}

机构：

[1] EXXON BIOMED SCI INC,E MILLSTONE,NJ 08875

来源：

TOXICOLOGIC PATHOLOGY | 1995年 / 23卷 / 01期

关键词：

HEPATIC; GRANULOMA; MICROGRANULOMA; MESENTERIC LYMPH NODE; HISTIOCYTOSIS;

D O I：

10.1177/019262339502300104

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

A 90-day study was conducted to compare the effects of dietary administration of a food-grade white oil in female Fischer-344 (F-344) and Sprague-Dawley-derived (CRL:CD) rats. Animals were fed a low viscosity (15 mm(2)/sec at 40 degrees C) paraffinic white oil (designated as P 15[H]) at 0, 0.2, or 2.0% of the diet for 30, 61, or 92 days. There were no significant adverse clinical observations or unscheduled deaths, In the F-344 rats, occasional treatment-related changes were seen in hematology and clinical chemistry parameters. At necropsy, mesenteric lymph nodes were enlarged, and there was an increase in absolute and relative liver, mesenteric lymph node, and spleen weights as compared to controls. Histopathologic effects included hepatic and mesenteric lymph node microgranulomas and mesenteric lymph node histiocytosis. In CRL:CD rats, the only effects noted were accumulations of chronic inflammatory cells in the liver at the high dose only, without the formation of discrete microgranulomas. A dose-related increase in mineral hydrocarbon (MHC) material in the liver and mesenteric lymph nodes was observed in both F-344 and CRL:CD rats. Although increased, liver MHC content was significantly less (approximately 50%) in CRL:CD rats than the levels detected in the F-344 rats. Mesenteric lymph node MHC levels did not differ significantly between the strains. This study demonstrated strain differences among rats in histopathologic effects of white oil, with the CRL:CD rat essentially showing no response compared to the F-344 rat. The differences in the pathologic responses between the 2 strains appears to result from the higher MHC tissue content and a greater sensitivity of the F-344 rat to the presence of the MHC material.

引用

页码：26 / 33

页数：8

共 14 条

[1] American P.I., Mineral Oil Review. HECRL:CD Report, 39-31651, (1992)
[2] Baldwin M.K., Berry P.H., Esdaile D.J., Linnett S.L., Martin J.G., Peristianis G.C., Priston R.A., Simpson B.J., Smith J.D., Feeding studies in rats with mineral hydrocarbon food grade white oils, Toxicol. Pathol., 20, pp. 426-435, (1992)
[3] Bird M.G., Lewis S.C., Freeman J.J., Smith J.H., Hogan G.K., Scala R.A., Subchronic feeding study of white mineral oils in rats and dogs, Toxicologist, 10, (1990)
[4] Concawe, Assessment and Comparison of the Composition of Food-Grade White Oils and Waxes Manufactured from Petroleum by Catalytic Hydrogenation Versus Conventional Treatment., (1984)
[5] Concawe, White Oil and WaxeslSummary of 90-Day Studies., (1993)
[6] Dixon W., Massey F., Introduction to Statistical Analysis, pp. 114-116, (1969)
[7] Dunnett C.W., New tables for multiple comparisons with a control, Biometrics., 20, pp. 482-491, (1964)
[8] Gilman A.G., Goodman L.S., Rall T.W., Murad F., Goodman and Gilman's the Pharmacological Basis of Therapeutics, (1985)
[9] Holland M., Wolf D.A., Nonparametric Statistical Methods., (1973)
[10] McKee R.H., Pasternak S.J., Traul K.J., Assessment of the potential reproductive and subchronic toxicity of EDS coal liquids in Sprague-Dawley rats, Toxicology, 46, pp. 267-280, (1987)

← 1 2 →