RELATIONSHIPS BETWEEN THE CARDIOVASCULAR EFFECTS, ALPHA-ADRENOCEPTOR AND BETA-ADRENOCEPTOR BLOCKING ACTIONS AND PLASMA-CONCENTRATION OF LABETALOL IN DOCA HYPERTENSIVE RATS

被引:11
作者
DREW, GM
HILDITCH, A
LEVY, GP
机构
[1] Department of Pharmacology, Glaxo-Allenburys Research (Ware) Ltd. Ware
关键词
D O I
10.3109/10641967909068627
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The relationships between the cardiovascular effects, α and βadrenoceptor blocking actions and plasma concentration of labetalol have been examined in conscious DOCA hypertensive rats. Labetalol (10, 30 and 100mg/kg p.o.) reduced resting heart rate; blood pressure was reduced only by the two higher doses. The effects lasted 5-24 hours. There was a highly significant correlation between the plasma labetalol concentration and its cardiovascular effects. During the labetalol-induced hypotension and bradycardia the vasopressor responses to intra-arterial injections of phenylephrine were reduced; the tachycardia and vasodepressor responses produced by intra-arterial injections of isoprenaline were also reduced. It is concluded that αand βadrenoceptor blockade probably account for the labetalol-induced decreases in resting blood pressure and heart rate respectively. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码:597 / 611
页数:15
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