ION-PAIR LIQUID-CHROMATOGRAPHIC ASSAY OF DECONGESTANTS AND ANTIHISTAMINES

被引：42

作者：

KOZIOL, TR ^{[1
]}

JACOB, JT ^{[1
]}

ACHARI, RG ^{[1
]}

机构：

[1] COOPER LABS INC,CEDAR KNOLLS,NJ 07927

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 09期

关键词：

Antihistaminics—analysis; ion‐pair liquid chromatography; various cough and cold preparations; structure‐activity relationships; Decongestants—analysis; Liquid chromatography; ion‐pair—analysis; decongestants and antibistaminics in various cough and cold preparations; Structure‐activity relationships—decongestants and antihistaminics;

D O I：

10.1002/jps.2600680920

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The quantitative determinations of combinations of anti‐histamine and decongestant drugs including phenylephrine, dl‐ephed‐rine, Φ‐ephedrine, phenylpropanolamine, pyrilamine, pheniramine, l‐ephedrine, chlorpheniramine, brompheniramine, oxymetazoline, naphazoline, and antazoline contained in solid and liquid dosage forms are described. All active ingredients except the ephedrine optical isomers were separated from other ingredients with ion‐paired high‐pressure liquid chromatography. Manipulation of the mobile phase either by changing the hydroalcoholic ratio or by changing the alkyl chain length of the counterion (sulfonic acid) for achieving optimum separations is discussed. The method is simple, short, accurate, and precise. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1135 / 1138

页数：4

共 3 条

[1]

GUPTA VD, 1977, J PHARM SCI, V66, P895

[2] HIGH-PRESSURE LIQUID-CHROMATOGRAPHIC DETERMINATION OF ADRENERGIC AND ANTIHISTAMINIC COMPOUNDS IN PHARMACEUTICAL PREPARATIONS [J].

SPRIECK, TL .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1974, 63 (04) :591-593

[3] SIMULTANEOUS DETERMINATION OF PSEUDOEPHEDRINE AND CHLORPHENIRAMINE IN PHARMACEUTICAL DOSAGE FORMS [J].

YACOBI, A ;

LOOK, ZM ;

LAI, CM .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1978, 67 (12) :1668-1670

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