EFFECT OF LONG-TERM USE OF NORPLANT IMPLANTS ON HEMOSTATIC FUNCTION

This study describes the effects of Norplant(R) on haemostatic function after 5 years of use in 97 women. There was a decrease in vitamin-K dependent Factors II, V, VII and reduction in fibrinolytic activity at 2 and 4 years of use. Increased platelet numbers and accelerated platelet aggregation were found throughout the 5 years of Norplant(R) use, whilst raised alpha2-Macroglobulin (a2-M) and antithrombin III (ATIII) antigen level were observed for up to 4 years of use. Prolonged Norplant(R) use does not appear to activate the coagulation system and does not enhance a state of hypercoagulation.