ANTICOAGULANT EFFECTS OF SULFONATED POLYURETHANES

被引：94

作者：

SILVER, JH

HART, AP

WILLIAMS, EC

COOPER, SL

CHAREF, S

LABARRE, D

JOZEFOWICZ, M

机构：

[1] UNIV WISCONSIN,DEPT CHEM ENGN,1415 JOHNSON DR,MADISON,WI 53706

[2] UNIV WISCONSIN,DEPT MED,MADISON,WI 53706

[3] UNIV PARIS 13,RECH MACROMOLEC LAB,F-93430 VILLETANEUSE,FRANCE

来源：

BIOMATERIALS | 1992年 / 13卷 / 06期

关键词：

BLOOD-MATERIAL INTERACTIONS; POLYURETHANES; SULFONATES;

D O I：

10.1016/0142-9612(92)90037-O

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Sulphonated polyurethanes have been shown to have excellent blood contacting properties. In this paper, similar polyurethanes which are water soluble have been investigated to determine their influence on thrombus formation. These polymers were shown to delay clotting times in the following ways: by direct complex formation between the polymer and thrombin; by interference with fibrin polymerization; and by complex interactions between polymer, thrombin, plasma antiproteases and fibrinogen in plasma.

引用

页码：339 / 344

页数：6

共 23 条

[1] RADIOIMMUNOASSAY OF HUMAN FIBRINOPEPTIDE-B AND KINETICS OF FIBRINOPEPTIDE CLEAVAGE BY DIFFERENT ENZYMES [J].