SYNTHESIS OF N-BOC-PROTECTED 1-AMINO-3-ALKEN-2-OLS FROM ALLYLIC CARBAMATES VIA PALLADIUM(II)-CATALYZED OXIDATIVE CYCLIZATION

被引：54

作者：

VANBENTHEM, RATM ^{[1
]}

HIEMSTRA, H ^{[1
]}

SPECKAMP, WN ^{[1
]}

机构：

[1] UNIV AMSTERDAM,DEPT ORGAN CHEM,NIEUWE ACHTERGRACHT 129,1018 WS AMSTERDAM,NETHERLANDS

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 23期

关键词：

D O I：

10.1021/jo00049a001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methyl glyoxylate adducts of N-Boc-protected allylic amines cyclize in the presence of catalytic Pd(OAc)2 and excess Cu(OAc)2 in DMSO to 5-(1-alkenyl)-2-(methoxycarbonyl)oxazolidines. These heterocycles are readily converted to unsaturated N-Boc-protected beta-amino alcohols through anodic oxidation and mild hydrolysis.

引用

页码：6083 / 6085

页数：3

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