THE 26-S PROTEASOME IS ACTIVATED AT 2 POINTS IN THE ASCIDIAN CELL-CYCLE

被引：31

作者：

KAWAHARA, H ^{[1
]}

SAWADA, H ^{[1
]}

YOKOSAWA, H ^{[1
]}

机构：

[1] HOKKAIDO UNIV,FAC PHARMACEUT SCI,DEPT BIOCHEM,SAPPORO,HOKKAIDO 060,JAPAN

来源：

FEBS LETTERS | 1992年 / 310卷 / 02期

关键词：

PROTEASOME; CELL CYCLE; CELL DIVISION; MITOSIS; ASCIDIAN CELL CYCLE;

D O I：

10.1016/0014-5793(92)81310-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The proteasome undergoes cell cycle-dependent changes in its subcellular distribution during ascidian embryonic development [(1992) Dev. Biol. 151, 27-33]. In this study, we demonstrate that the 26 S proteasome is markedly activated in both prophase and metaphase of the mitotic cell cycle in the ascidian embryos in comparison with the case of the 20 S proteasome. These results suggest that the 26 S proteasome is activated and participates in proteolysis at the restricted stages of the cell cycle.

引用

页码：119 / 122

页数：4

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