OROPHARYNGEAL DECONTAMINATION - BIOADHESIVE POWDER MIXTURE FORMULATION .1. CHOICE OF THE BIOADHESIVE MATERIAL

被引：8

作者：

CHARRUEAU, C

ARNAUD, P

DURIEUX, J

ALLAIN, P

CHAUMEIL, JC

机构：

[1] UNIV PARIS 05,FAC PHARM,PHARMACOTECH LAB,F-75270 PARIS 06,FRANCE

[2] HOP PARIS,SERV MISE POINT GALEN,F-75005 PARIS,FRANCE

来源：

JOURNAL OF CONTROLLED RELEASE | 1993年 / 26卷 / 01期

关键词：

GELATION; IN-VITRO BIOADHESION; OROPHARYNGEAL DECONTAMINATION; POWDER FORM; WETTABILITY;

D O I：

10.1016/0168-3659(93)90208-M

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The aim of this study was to improve the administration form of the oropharyngeal decontaminating mixture manufactured at the ''Pharmacie Centrale des Hopitaux de Paris''. Five tests (slide, Nogami apparatus, tablet, coagulation automator and in vitro bioadhesion) were carried out with 19 products with the aim of selecting the product best fitted to the administration form: a powder dispersed in the buccal cavity, bioadhesive in situ, and forming a gel with saliva. Natrosol 250 HHX Pharm(R) (H.E.C.) was chosen for its wetting and bioadhesive properties as well as its gelation rate.

引用

页码：49 / 57

页数：9

共 22 条

[1] EVALUATION OF LAMINATED MUCO-ADHESIVE PATCHES FOR BUCCAL DRUG DELIVERY [J].