CLONING AND ANALYSIS OF A LOCUS (MCR) INVOLVED IN MITOMYCIN-C RESISTANCE IN STREPTOMYCES-LAVENDULAE

被引：52

作者：

AUGUST, PR

FLICKINGER, MC

SHERMAN, DH

机构：

[1] UNIV MINNESOTA,INST BIOL PROC TECHNOL,GORTNER LAB 240,ST PAUL,MN 55108

[2] UNIV MINNESOTA,DEPT MICROBIOL,ST PAUL,MN 55108

[3] UNIV MINNESOTA,DEPT BIOCHEM,ST PAUL,MN 55108

来源：

JOURNAL OF BACTERIOLOGY | 1994年 / 176卷 / 14期

关键词：

D O I：

10.1128/jb.176.14.4448-4454.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two genes (mcrA and mcrB) from Streptomyces lavendulae that together confer resistance to mitomycin C were identified. This DNA appears to comprise a polycistronic operon with a drug-inducible leaderless mRNA. The deduced amino acid sequence of mcrA shows similarity to sequences of a special class of bacterial, plant, and animal oxygen oxidoreductases.

引用

页码：4448 / 4454

页数：7

共 32 条

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