MICROBIAL GENERATION OF (2R,3S)-ETHYL AND (2S,3S)-ETHYL 2-BENZAMIDOMETHYL-3-HYDROXYBUTYRATE, A KEY INTERMEDIATE IN THE SYNTHESIS OF (3S,1'R)-3-(1'-HYDROXYETHYL)AZETIDIN-2-ONE

被引：13

作者：

FUGANTI, C ^{[1
]}

LANATI, S ^{[1
]}

SERVI, S ^{[1
]}

TAGLIANI, A ^{[1
]}

BEDESCHI, A ^{[1
]}

FRANCESCHI, G ^{[1
]}

机构：

[1] FARMITALIA CARLO ERBA SPA,RES & DEV,I-20014 NERVIANO,ITALY

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 19期

关键词：

D O I：

10.1039/p19930002247

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Microbial reduction of the carbonyl group of the substituted acetoacetate esters 3-6 affords directly, or after Ni-Raney desulfurization, the corresponding enantiomerically pure 3S carbinols of variable diastereoisomeric composition. These compounds are transformed into (3S,1'R)-3-(1'-hydroxyethyl)-azetidin-2-one, a useful intermediate in the synthesis of beta-lactam antibiotics.

引用

页码：2247 / 2249

页数：3

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