CURRENT PERSPECTIVES IN REACTIVE ARTHRITIS

被引:69
作者
KINGSLEY, G
SIEPER, J
机构
[1] DEUTSCH RHEUMAFORSCH ZENTRUM,BERLIN,GERMANY
[2] FREE UNIV BERLIN,W-1000 BERLIN 33,GERMANY
来源
IMMUNOLOGY TODAY | 1993年 / 14卷 / 08期
关键词
D O I
10.1016/0167-5699(93)90139-C
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Reactive arthritis (ReA) is an inflammatory arthritis triggered by infection, usually urethritis or gastroenteritis, and is strongly associated with the MHC class I antigen HLA-B27. Two recent observations have excited interest: first, antigen and DNA from the triggering bacteria have been identified in the joint and, second, ReA synovial T cells have been found to respond specifically to the bacterium that caused the initiating infection. Because the trigger of ReA, its onset and the MHC association are all clearly defined, we can investigate hypotheses that are impossible to study in other forms of human arthritis. Here, Gabrielle Kingsley and Jochen Sieper review the topic in the light of a recent workshop.
引用
收藏
页码:387 / 391
页数:5
相关论文
共 37 条
[1]   ORAL SALMONELLA - MALARIA CIRCUMSPOROZOITE RECOMBINANTS INDUCE SPECIFIC CD8+ CYTOTOXIC T-CELLS [J].
AGGARWAL, A ;
KUMAR, S ;
JAFFE, R ;
HONE, D ;
GROSS, M ;
SADOFF, J .
JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (04) :1083-1090
[2]   GUILT BY ASSOCIATION - HLA-B27 AND ANKYLOSING-SPONDYLITIS [J].
BENJAMIN, R ;
PARHAM, P .
IMMUNOLOGY TODAY, 1990, 11 (04) :137-142
[3]   REITERS DISEASE AND HL-A 27 [J].
BREWERTON, DA ;
NICHOLLS, A ;
OATES, JK ;
CAFFREY, M ;
WALTERS, D ;
JAMES, DCO .
LANCET, 1973, 2 (7836) :996-998
[4]  
CHIECOBIANCHI F, 1992, ARTHRITIS RHEUM, V35, pS64
[5]  
FIDLER MF, 1993, BRIT MED J, V306, P546
[6]   LYMPHOCYTES FROM THE SITE OF DISEASE BUT NOT BLOOD-LYMPHOCYTES INDICATE THE CAUSE OF ARTHRITIS [J].
FORD, DK ;
DAROZA, DM ;
SCHULZER, M .
ANNALS OF THE RHEUMATIC DISEASES, 1985, 44 (10) :701-710
[7]  
GASTON JSH, 1990, CLIN EXP IMMUNOL, V82, P1
[8]  
GASTON JSH, 1989, CLIN EXP IMMUNOL, V76, P348
[9]  
GOODALL J, 1993, BR J RHEUMATOL S1, V32, P105
[10]   YERSINIA ANTIGENS IN SYNOVIAL-FLUID CELLS FROM PATIENTS WITH REACTIVE ARTHRITIS [J].
GRANFORS, K ;
JALKANEN, S ;
VONESSEN, R ;
LAHESMAARANTALA, R ;
ISOMAKI, O ;
PEKKOLAHEINO, K ;
MERILAHTIPALO, R ;
SAARIO, R ;
ISOMAKI, H ;
TOIVANEN, A .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (04) :216-221