EFFECTS OF NEUROPEPTIDE-Y ON LUNG VASCULAR-PERMEABILITY IN THE PULMONARY CIRCULATION OF RATS

被引：6

作者：

HIRABAYASHI, A

NISHIWAKI, K

TAKI, K

SHIMADA, Y

ISHIKAWA, N

机构：

[1] AICHI PREFECTURAL INST PUBL HLTH,BIOL SECT,KITA KU,NAGOYA 462,JAPAN

[2] NAGOYA UNIV,SCH MED,DEPT ANESTHESIOL,SHOWA KU,NAGOYA,AICHI 466,JAPAN

[3] NAGOYA UNIV,SCH MED,SURG OPERAT SECT,SHOWA KU,NAGOYA,AICHI 466,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 256卷 / 02期

关键词：

PULMONARY EDEMA; NEUROTRANSMITTER; NEUROPEPTIDE Y; NEUROKININ A;

D O I：

10.1016/0014-2999(94)90251-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of neuropeptides on the capillary filtration coefficient in the vessels of the pulmonary circulation were examined, using isolated lung perfusion preparations from rats. Neuropeptide Y and neurokinin A elevated the filtration coefficient, and calcitonin gene related peptide diminished it. Neurotensin and substance P did not affect the value at concentrations less than 10(-7) M. The number of extravasated carbon particle deposits subsequent to tracheal application of neuropeptide Y during spontaneous respiration increased in a dose-dependent manner. From these results, we conclude that neuropeptide Y may increase vascular permeability in the pulmonary circulation.

引用

页码：227 / 230

页数：4

共 10 条

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GAAR KA, 1967, AM J PHYSIOL, V213, P910

[2] NEUROPEPTIDE-Y, PEPTIDE-YY AND C-TERMINAL FRAGMENTS RELEASE HISTAMINE FROM RAT PERITONEAL MAST-CELLS [J].