EFFECT OF SULFHYDRYL BLOCKADE ON INSULIN ACTION AND GLUCOSE TRANSPORT IN ISOLATED ADIPOSE TISSUE CELLS

被引：44

作者：

CARTER, JR

MARTIN, DB

机构：

[1] Diabetes Unit, Medical Services, Massachusetts General Hospital

[2] Department of Medicine, Harvard Medical School, Boston

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1969年 / 177卷 / 03期

关键词：

D O I：

10.1016/0304-4165(69)90314-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of sulfhydryl blockade on glucose metabolism have been investigated using isolated adipose tissue cells from the rat and the specific sulfhydryl binding agent, N-ethylmaleimide. According to the conditions of the experiment, there can be (1) an insulin-like effect, (2) inhibition of insulin-stimulated glucose metabolism, and (3) inhibition of basal glucose metabolism. At least the first two effects appear to occur at the level of membrane transport. © 1969.

引用

页码：521 / &

共 19 条

[1]

CADENAS E, 1961, J BIOL CHEM, V236, pPC63

[2]

COHEN PP, 1949, MANOMETRIC TECHNIQUE, P119

[3]

CROFFORD OB, 1968, J CLIN INVEST, V47, pA23

[4] INHIBITION OF GLUCOSE PERMEABILITY OF HUMAN ERYTHROCYTES BY N-ETHYL MALEIMIDE [J].

DAWSON, AC ;

WIDDAS, WF .

JOURNAL OF PHYSIOLOGY-LONDON, 1963, 168 (03) :644-&

[5] EFFECTS OF METAL IONS AND SULFHYDRYL INHIBITORS ON GLUCOSE METABOLISM BY ADIPOSE TISSUE [J].

DIXIT, PK ;

LAZAROW, A .

AMERICAN JOURNAL OF PHYSIOLOGY, 1967, 213 (04) :849-&

[6]

DOLE VP, 1960, J BIOL CHEM, V235, P2595

[7] THE STABILITY OF N-ETHYLMALEIMIDE AND ITS REACTION WITH SULFHYDRYL GROUPS [J].

GREGORY, JD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1955, 77 (14) :3922-3923

[8] EFFECTS OF SULFHYDRYL INHIBITION ON RED BLOOD CELLS .1. MECHANISM OF HEMOLYSIS [J].

JACOB, HS ;

JANDL, JH .

JOURNAL OF CLINICAL INVESTIGATION, 1962, 41 (04) :779-&

[9] EFFECTS OF ARSENITE ON LIPOLYSIS AND METABOLISM OF GLUCOSE PALMITIC ACID AND AMINO ACIDS BY ISOLATED ADIPOSE CELLS [J].

KUO, JF ;

DILL, IK ;

HOLMLUND, CE .

BIOCHIMICA ET BIOPHYSICA ACTA, 1967, 148 (03) :683-&

[10]

LYNN WS, 1961, J CLIN INVEST, V40, P1059

← 1 2 →