CIRCULATING FILARIAL ANTIGEN IN CATS INFECTED WITH BRUGIA-PAHANGI IS INDICATIVE OF THE PRESENCE OF ADULT WORMS

被引：4

作者：

KUMAR, H ^{[1
]}

BALDWIN, C ^{[1
]}

BIRCH, DW ^{[1
]}

DENHAM, DA ^{[1
]}

DEMEDEIROS, F ^{[1
]}

MIDWINTER, ITC ^{[1
]}

SMAIL, A ^{[1
]}

机构：

[1] UNIV LONDON LONDON SCH HYG & TROP MED,KEPPEL ST,LONDON WC1E 7HT,ENGLAND

来源：

PARASITE IMMUNOLOGY | 1991年 / 13卷 / 04期

关键词：

FILARIASIS; BRUGIA-PAHANGI; CATS; CIRCULATING ANTIGEN; COUNTERIMMUNOELECTROPHORESIS;

D O I：

10.1111/j.1365-3024.1991.tb00293.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Using counterimmunoelectrophoresis with rabbit antisera raised against soluble extracts of adult females of Brugia pahangi parasite antigen was detected in the serum of all cats repeatedly infected with B. pahangi. Antigen was never detected in uninfected cats. The antigen was associated with the presence of adult worms. Antigen was detected consistently in a cat that was amicrofilaraemic but at autopsy harboured only two or three adult worms. Conversely, some cats showed slowly declining numbers of microfilariae and, in these, circulating antigen declined before the number of microfilariae. Eventually no antigen was detectable in circulation whereas microfilariae, although in diminishing numbers, were still present. At autopsy no adult worms were found in these cats. Antigen also appeared in several cats before they became microfilaraemic.

引用

页码：405 / 412

页数：8

共 19 条

[1]

Au A C, 1981, Southeast Asian J Trop Med Public Health, V12, P492

[2] IMPROVED STAIN FOR IMMUNODIFFUSION TESTS [J].

CROWLE, AJ ;

CLINE, LJ .

JOURNAL OF IMMUNOLOGICAL METHODS, 1977, 17 (3-4) :379-381

[3] LYMPHATIC FILARIASIS IN MAN - DEMONSTRATION OF CIRCULATING ANTIGENS IN WUCHERERIA-BANCROFTI INFECTION [J].

DASGUPTA, A ;

BALA, S ;

DUTTA, SN .

PARASITE IMMUNOLOGY, 1984, 6 (04) :341-348

[4]

Denham D A, 1972, Int J Parasitol, V2, P401, DOI 10.1016/0020-7519(72)90084-7

[5]

DENHAM DA, 1987, CIBA F SYMP, V127, P225

[6] COMPARISON OF A COUNTING CHAMBER AND THICK SMEAR METHODS OF COUNTING MICROFILARIAE [J].

DENHAM, DA ;

DENNIS, DT ;

PONNUDUR.T ;

NELSON, GS ;

GUY, F .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1971, 65 (04) :521-+

[7] THE RESISTANCE TO RE-INFECTION OF CATS REPEATEDLY INOCULATED WITH INFECTIVE LARVAE OF BRUGIA-PAHANGI [J].

DENHAM, DA ;

MCGREEVY, PB ;

SUSWILLO, RR ;

ROGERS, R .

PARASITOLOGY, 1983, 86 (FEB) :11-18

[8] DETECTION OF ANTIBODIES IN HUMAN AND ANIMAL FILARIASES BY COUNTERIMMUNOELECTROPHORESIS WITH DIROFILARIA-IMMITIS ANTIGENS [J].

DESOWITZ, RS ;

UNA, SR .

JOURNAL OF HELMINTHOLOGY, 1976, 50 (01) :53-57

[9] BRUGIA-PAHANGI INFECTIONS IN CATS - ANTIBODY-RESPONSES WHICH CORRELATE WITH THE CHANGE FROM THE MICROFILAREMIC TO THE AMICROFILAREMIC STATE [J].

FLETCHER, C ;

BIRCH, DW ;

SAMAD, R ;

DENHAM, DA .

PARASITE IMMUNOLOGY, 1986, 8 (04) :345-357

[10]

FORSYTH KP, 1985, J IMMUNOL, V134, P1172

← 1 2 →