ELUCIDATION AND OPTIMIZATION OF THE MEDIUM CONSTITUENTS CONTROLLING ANTIBIOTIC PRODUCTION BY THE CYANOBACTERIUM NOSTOC-MUSCORUM

被引：47

作者：

BLOOR, S ^{[1
]}

ENGLAND, RR ^{[1
]}

机构：

[1] LANCASHIRE POLYTECH,SCH APPL BIOL,PRESTON PR1 2TQ,ENGLAND

来源：

ENZYME AND MICROBIAL TECHNOLOGY | 1991年 / 13卷 / 01期

关键词：

CYANOBACTERIUM; NOSTOC-MUSCORUM; ANTIBIOTIC; OPTIMIZATION;

D O I：

10.1016/0141-0229(91)90192-D

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A study has been made to determine which nutrient factors control antibiotic production by the cyanobacterium, Nostoc muscorum. A two-phase approach was employed using a factorial method to explore the response surface and a steepest ascent method to climb the response surface to the region of the optimum. It was found that nitrate and iron were the factors significantly affecting antibiotic production; 26.4 mM nitrate and 6-mu-m iron were the optimal concentrations for maximizing antibiotic production by N. muscorum.

引用

页码：76 / 81

页数：6

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