DETECTION OF HEPATIC MALIGNANCIES USING MN-DPDP (MANGANESE DIPYRIDOXAL DIPHOSPHATE) HEPATOBILIARY MRI CONTRAST AGENT

被引：30

作者：

YOUNG, SW

BRADLEY, B

MULLER, HH

RUBIN, DL

机构：

[1] Department of Diagnostic Radiology and Nuclear Medicine, Stanford University School of Medicine, Stanford

来源：

MAGNETIC RESONANCE IMAGING | 1990年 / 8卷 / 03期

关键词：

Cancer; Contrast agents; Liver; Mn-DPDP; MRI; V2; carcinoma;

D O I：

10.1016/0730-725X(90)90099-N

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A new hepatobiliary contrast agent (Mn-DPDP) was used in the detection of liver metastases in six rabbits with seven hepatic V2 carcinomas. This contrast agent is derived from pyridoxyl-5-phosphate which is biomimetically designed to be secreted by the hepatocyte. After Mn-DPDP administration, a 105% increase in liver signal to noise was obtained using a 200 20 ( TR TE) pulsing sequence, and a 62% decrease in intensity was observed using a 1200 60 pulsing sequence. Liver V2 carcinoma contrast enhancement increased 427% using the 200 20 pulsing sequence and 176% using the 1200 60 pulsing sequence. Four of seven V2 carcinomas were not detectable prior to the administration of Mn-DPDP (50 μmol/kg). Two neoplasms were only detectable in retrospect (after Mn-DPDP) on the 1200 60 sequence. The smallest neoplasms detected in this study were 1-4 mm. Mn-DPDP appears to be a promising MRI contrast agent. © 1990.

引用

页码：267 / 276

页数：10

共 26 条

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