PUVA SUPPRESSES THE PROLIFERATIVE STIMULUS PRODUCED BY STRIPPING ON HAIRLESS MICE

被引：23

作者：

FRITSCH, PO

GSCHNAIT, F

KAASERER, G

BRENNER, W

CHAIKITTISILPA, S

HONIGSMANN, H

WOLFF, K

机构：

[1] VIENNA UNIV, DEPT DERMATOL I, A-1010 VIENNA, AUSTRIA

[2] UNIV BANKOK, DEPT DERMATOL, BANKOK, THAILAND

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 1979年 / 73卷 / 02期

关键词：

D O I：

10.1111/1523-1747.ep12581676

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Hairless mice were fed with 8-methoxypsoralen by gastric tube and exposed to UVA light to produce threshold phototoxic reactions. 3H-thymidine autoradiography revealed no significant difference of the epidermal labeling index as compared to that of nonirradiated animals (4.8 vs 6.2). Single PUVA exposures performed 2, 8, 14 and 24 hr after tape stripping lead to suppression of a wave of synchronized DNA synthesis present in nonirradiated control animals. These data demonstrate different reactions of stripped and unstripped epidermis to PUVA exposures and offer indirect evidence for the suppression of DNA synthesis in hyperproliferative skin disorders by PUVA in vivo.

引用

页码：188 / 190

页数：3

共 19 条

[1] DNA-SYNTHESIS IN NORMAL AND XERODERMA PIGMENTOSUM FIBROBLASTS FOLLOWING TREATMENT WITH 8-METHOXYPSORALEN AND LONG WAVE ULTRAVIOLET-LIGHT [J].