ANTIARTHRITIC ACTIVITY OF THE NEWLY DEVELOPED NEUTROPHIL OXIDATIVE BURST ANTAGONIST APOCYNIN

被引：77

作者：

THART, BA

SIMONS, JM

KNAANSHANZER, S

BAKKER, NPM

LABADIE, RP

机构：

[1] Department of Chronic and Infectious Diseases, TNO Institute for Applied Radiobiology and Immunology, Rijswijk

[2] Department of Pharmacognosy, Faculty of Pharmacy, University of Utrecht

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 9卷 / 02期

关键词：

Apocycnin; Collagen-arthritis; Free radicals; Reactive oxygen species;

D O I：

10.1016/0891-5849(90)90115-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The plant-phenol 4-hydroxy-3-methoxyacetophenone (trivial name apocynin) is a strong inhibitor of neutrophil superoxide anion (O2-) release in vitro. In vitro the inhibitory effect of apocynin is restricted to cells with the capacity to release peroxidase and reactive oxygen species (ROS). Peroxidase deficient cells are insensitive to apocynin. In the present study the antinflammatory activity of apocynin in the drinking water starting at the onset of joint-swelling and terminating 14 days later, at the time when joint swelling in the control group was maximal. Apocynin-treated animals had a normal plasma level of collagen-specific antibodies, but showed a significant reduction of the joint swelling. Also the plasma IL-6 level in apocynin-treated animals was substantially lower than in control animals. No flare-up of joint swelling after termination of the treatment was observed in the apocynin-treated groups. © 1990.

引用

页码：127 / 131

页数：5

共 22 条

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