CHIRALITY IN ANTIRHEUMATIC DRUGS

被引：99

作者：

KEAN, WF

LOCK, CJL

HOWARDLOCK, HE

机构：

[1] MCMASTER UNIV,DEPT MED,INORGAN MED LABS,HAMILTON L8S 4L8,ONTARIO,CANADA

[2] MCMASTER UNIV,DEPT PATHOL,HAMILTON L8S 4L8,ONTARIO,CANADA

[3] MCMASTER UNIV,DEPT CHEM,HAMILTON L8S 4L8,ONTARIO,CANADA

来源：

LANCET | 1991年 / 338卷 / 8782-3期

关键词：

D O I：

10.1016/0140-6736(91)92382-C

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Use of chiral molecules in clinical practice may cause problems because different chiral forms of a drug (enantiomers) may have different biological activities clinicians have little awareness of these risks. After discussion of the chemical conventions used to describe chirality, examples of the influence of chirality on the efficacy and toxicity of antirheumatic drugs are given. It is recommended that single enantiomers should be used in biological experiments and clinical trials.

引用

页码：1565 / 1568

页数：4

共 27 条

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