AN NMR-STUDY OF THE INTERACTION BETWEEN MELANIN FREE ACID AND MN2+ IONS AS A MODEL TO MIMIC THE ENHANCED PROTON RELAXATION RATES IN MELANOTIC MELANOMA

被引：9

作者：

AIME, S

FASANO, M

TERRENO, E

SARZANINI, C

MENTASTI, E

机构：

[1] Dipartimento di Chimica Inorganica, Chimica Fisica e Chimica dei Materiali, Università degli Studi di Torino, 10125 Torino

[2] Dipartimento di Chimica Analitica, Università degli Studi di Torino, 10125 Torino

来源：

MAGNETIC RESONANCE IMAGING | 1991年 / 9卷 / 06期

关键词：

CPMAS; MELANIN; MELANOMA; MRI; NMRD; PRE;

D O I：

10.1016/0730-725X(91)90544-V

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The interaction of a soluble Melanin Free Acid (MFA) from Sepia melanin with Mn2+ ions is investigated by measuring the proton water relaxation rates. The similarity between MFA and the parent melanin is assessed by means of their high resolution C-13 cross polarization magic angle spinning NMR spectra. The observed marked increase in longitudinal proton relaxation rates and the characteristic 1/T1 NMRD profile are associated to the formation of a macromolecular metal complex. The presence of similar paramagnetic species is expected to cause the high contrast shown by melanotic tissues in MRI.

引用

页码：963 / 968

页数：6

共 14 条

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