SEA-ANEMONE RADIANTHUS-MACRODACTYLUS - A NEW SOURCE OF PALYTOXIN

被引:26
作者
MAHNIR, VM
KOZLOVSKAYA, EP
KALINOVSKY, AI
机构
[1] Pacific Institute of Bioorganic Chemistry, Russian Academy of Sciences, Vladivostok
关键词
D O I
10.1016/0041-0101(92)90520-F
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A very potent non-protein toxin was isolated from the sea anemone Radianthus macrodactylus with the use of chromatography on polytetrafluoroethylene, CM-Sephadex C-25 and by cation and anion exchange HPLC. The toxin was identified as palytoxin by u.v.-, i.r.- and 500 MHz H-1 NMR spectroscopy. ItS LD50 was 0.74 +/- 0.29 mug/kg by i.v. injection into mice. So far, palytoxin has been associated with zoanthids only. The toxin caused the loss of haemoglobin from erythrocytes but only in about 2 hr after the beginning of incubation, which is characteristic for palytoxin from zoanthids. Sea anemone palytoxin was divided into major and minor components by HPLC. The latter proved to be a product of degradation of palytoxin.
引用
收藏
页码:1449 / 1456
页数:8
相关论文
共 18 条
[1]   A METHOD FOR THE ISOLATION OF THE CARIBBEAN PALYTOXIN (C-PTX) FROM THE COELENTERATE (ZOOANTHID) PALYTHOA-CARIBAEORUM [J].
BERESS, L ;
ZWICK, J ;
KOLKENBROCK, HJ ;
KAUL, PN ;
WASSERMANN, O .
TOXICON, 1983, 21 (02) :285-290
[2]   BIOLOGICALLY-ACTIVE COMPOUNDS FROM COELENTERATES [J].
BERESS, L .
PURE AND APPLIED CHEMISTRY, 1982, 54 (10) :1981-1994
[3]  
BREZHESTOVSKII PD, 1988, DOKL AKAD NAUK SSSR+, V299, P748
[4]   PALYTOXIN ACTS THROUGH NA+,K+-ATPASE [J].
HABERMANN, E .
TOXICON, 1989, 27 (11) :1171-1187
[5]   DELAYED HEMOLYTIC ACTION OF PALYTOXIN GENERAL-CHARACTERISTICS [J].
HABERMANN, E ;
AHNERTHILGER, G ;
CHHATWAL, GS ;
BERESS, L .
BIOCHIMICA ET BIOPHYSICA ACTA, 1981, 649 (02) :481-486
[6]  
HIRATA Y, 1981, 1ST P INT C CHEM BIO, P79
[7]   PALYTOXIN - MECHANISM OF ACTION OF A POTENT MARINE TOXIN [J].
IBRAHIM, AR ;
SHIER, WT .
JOURNAL OF TOXICOLOGY-TOXIN REVIEWS, 1987, 6 (02) :159-187
[8]  
Kem W.R., 1988, P375
[9]  
LOWRY OH, 1951, J BIOL CHEM, V193, P265
[10]   MODIFICATION OF CARBOXYL GROUPS IN SEA-ANEMONE TOXIN RTX-III FROM RADIANTHUS-MACRODACTYLUS [J].
MAHNIR, VM ;
KOZLOVSKAYA, EP ;
ELYAKOV, GB .
TOXICON, 1990, 28 (11) :1255-1263