DOES THE GENDER DIFFERENCE IN INTERFERON-PRODUCTION SEEN IN PICORNAVIRUS-INFECTED SPLEEN-CELL CULTURES FROM ICR SWISS MICE HAVE ANY IN-VIVO SIGNIFICANCE

被引:16
作者
CURIEL, RE [1 ]
MILLER, MH [1 ]
ISHIKAWA, R [1 ]
THOMAS, DC [1 ]
BIGLEY, NJ [1 ]
机构
[1] WRIGHT STATE UNIV, DEPT MICROBIOL & IMMUNOL, DAYTON, OH 45435 USA
来源
JOURNAL OF INTERFERON RESEARCH | 1993年 / 13卷 / 06期
关键词
D O I
10.1089/jir.1993.13.387
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Splenocyte cultures from female ICR Swiss mice produced greater interferon (IFN) levels, particularly IFN-gamma, than did cultures from males by 12 h post-infection (pi) with the D variant of encephalomyocarditis virus (EMCV-D). This early IFN-gamma is produced by natural killer (NK)-like cells and is dependent on plastic adherent cells and IFN-alpha/beta.((1,2)) In this study, we evaluated the significance of this observation on the innate resistance of ICR Swiss females to EMCV-D-mediated disease. Treatment of females with rabbit anti-mouse IFN-alpha/beta serum rendered them susceptible to the diabetogenicity of EMCV-D. Although sera from both sexes of ICR Swiss mice exhibited peak IFN levels day 3 pi, IFN-gamma was present in the sera of males at only 1 day pi and in the sera of females at days 1-3 pi. Females cleared virus from the circulation by day 2 pi, 1 day earlier than did males. Flow cytometric evaluations of lymphoid cell phenotypes in spleens and pancreata of infected mice revealed that percentages of L3T4(+) cells were significantly decreased only in spleens from males at day 1 pi and were diminished along with Ly2(+) cells in pancreata of males at 7 days pi, suggesting that T-cell responses were impaired in virus-infected males.
引用
收藏
页码:387 / 395
页数:9
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